Now Alzheimer's can be completely cured, green tea has become a boon; scientists have developed a new medicine.

News Topical, Digital Desk : A major breakthrough has been achieved in the treatment of Alzheimer's disease (AD). Scientists at the Mohali-based Institute of Nano Science and Technology (INST) have developed a new nanoparticle-based treatment method. A protein found in green tea has been combined with three other proteins to create a drug that will alleviate many of the problems caused by Alzheimer's. The Ministry of Science and Technology is calling this a major achievement. Preparations for the patent process and clinical trials have begun.

Dr. Jeevan Jyoti Panda, Associate Professor at INST, who led the research team, explains that the new method is based on nanoparticles. It combines the antioxidant found in green tea (EGCG) with the neurotransmitter dopamine (EDTNP) and the amino acid tryptophan, which are involved in mood and neurotransmitters. The combination of all three proteins results in the development of a neurotransmitter called tryptophan (DTP). Dr. Jeevan Jyoti (fourth from right) with her team at INST.

EGCG-dopamine-tryptophan (EDTNP) nanoparticles were created. Brain-derived neurotrophic factor (BDNF) was also conjugated to these nanoparticles, creating an advanced nanoplatform that not only clears toxic amyloid beta protein deposits in the brain but also promotes neuronal regeneration and function. They explained that BDNF is a protein essential for neuronal survival, growth, and function. Addition of BDNF to EDTNP (β-EDTNP) creates a dual-action nanoplatform that not only clears neurotoxic amyloid beta aggregates (clumps of protein that negatively impact neural function) but also promotes neuronal regeneration.

Improved memory and learning ability

The research was co-authored by Dr. Ashok Kumar Datusalia of the National Institute of Pharmaceutical Education and Research (NIPER) in Raebareli and Dr. Neesha Singh of the Gujarat Biotechnology University in Gandhinagar. Dr. Ashok explained that laboratory tests and trials on mice showed improvements in memory and learning . Inflammation in the Alzheimer's brain was reduced and balance within cells was restored. Computer simulations confirmed the breakdown of harmful proteins.

Earlier one problem was solved, now four will provide relief.  

According to Dr. Jeevan Jyoti, Alzheimer's causes protein clumps to form in the brain, inflammation , increased oxidative stress, and brain cells to die. Older medications target only one problem, while the newer medication will target four key problems: amyloid deposition, oxidative stress, inflammation, and nerve cell loss. The combination of these leads to memory loss and the person's inability to think and function like a normal person.

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