Are calcium and vitamin D enough? AIIMS reveals the real reason behind bone loss after menopause.

News Topical, Digital Desk : Millions of women are suffering from problems like pain and frequent fractures due to bone weakness after menopause. New research by All India Institute of Medical Sciences (AIIMS), New Delhi has increased the hope of its effective treatment. According to the research, calcium or vitamin-D deficiency is not the only cause of this disease, but imbalance of intestine, immune system and bones is also responsible. AIIMS research has opened the way for developing targeted medicine. 

Understand the real root of the disease 

Hormonal changes after menopause affect beneficial gut bacteria and the immune system. This can lead to increased activity of bone-degrading cells (osteoclasts), leading to a rapid loss of bone density. 

Research raises hope 

The AIIMS research modeled post-menopausal osteoporosis and studied it in mice. A safe pro-bacteria called "Bacillus coagulus" was used. The study found that intestinal inflammation decreased and bone density improved significantly. Based on the positive results in mice, human clinical trials are now underway. 

Bone erosion may be reduced 

Bacillus coagulans increases the levels of short-chain fatty acids, especially butyrate, produced in the intestine. This same compound controls inflammation and slows bone loss. This principle will form the basis of the new drug. 

expert opinion

Dr. JB Sharma (former professor of gynecology and obstetrics, AIIMS, Delhi) explains that osteoporosis is a silent disease in postmenopausal women. By the time a fracture occurs, it's often too late. If a drug is developed that targets the gut and immune system, it could significantly change treatment approaches.

Dr. Rupesh Srivastava (Department of Biotechnology, AIIMS, New Delhi) explains that the study clearly demonstrates that postmenopausal osteoporosis is not solely a calcium deficiency disease. It stems from a disruption in the balance between the gut, immune system, and bones. The positive results in mice will lay a strong foundation for the development of a targeted drug in the future.

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